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Ear Mites

Advocate®: Effective Against Ear Mites

Ear mites (Otodectes cynotis) are psoroptic mites which infest the skin of the outer ear canal in both cats and dogs.

The Parasite

They live on the skin surface rather than burrowing, and may occasionally be found on the adjacent skin of the head.

The mites feed in the outer ear canal, causing irritation of the epithelial lining. The canal becomes full of cerumen, blood and mite feces, giving rise to a characteristic otitis externa of parasitic origin. Occasionally mites may be found on the adjacent skin of the head. Adults are large and white.

Females are 500 x 300 µm in size. The first two pairs of legs for all stages bear unjointed, short stalks and suckers (Fig. 1), while only the males have suckers on the rear legs. Male adults are 395 x 295 µm in size (Fig. 2).


Fig. 1: Otodectes cynotis female with a visible egg

Fig. 2: Otodectes cynotis male

It is the most common mange mite of cats and dogs in the world1, and it has been estimated that over 50% of otitis externa cases in dogs and 85% of cases in cats involve infestations with Otodectes2. It can give rise to intense pruritus, with the animal displaying frequent head shaking and scratching at the ears. This in turn can lead to aural hematoma formation and ulceration of the ear canal.

Life Cycle

The life cycle of Otodectes is similar to that of all other mites, i.e. development from egg to adult via a larval and two nymphal stages. Development time is about 3 weeks.

Otodectes larvae feed for 3 to 10 days, rest for a short time and then molt to become a protonymph. This nymphal stage is rather short and leads to the telonymph; once the female reaches this stage copulation occurs with an adult male mite. Fertilization only occurs, however, after the female telonymph has molted to become an adult female.

The life span of adult mites is about 2 months. Young animals are most susceptible to infestation and, as the mites are highly contagious and not host-specific, all in-contact animals should be presumed to be infected.

To watch or download the animation of this life cycle please visit our download area.

Pathogenesis and Clinical Appearance

Otodectes mites feed in the outer ear canal and cause irritation of the epithelial lining. The canal becomes full of cerumen, blood and mite feces and gives rise to a characteristic otitis externa of parasitic origin.

Although the clinical symptoms may vary, Otodectes are often seen in cats. The amount of discharge present is not always related to the severity of clinical signs – some cats with heavy discharge show no signs, whereas others with minimal discharge have intense pruritus.

The ear mite is very annoying to the host animal. The physical presence of the mite induces a mechanical irritation that accounts for some of the pruritus, but, in addition, mite saliva is an irritant and immunogenic. There is no delayed hypersensitivity, but reaginic antibodies develop early during infestation, followed by precipitating antibodies. The presence of an IgE-like antibody in the cat suggests that hypersensitivity also contributes to the pruritus.


Fig. 4: Typical debris in the ear of a cat infected with ear mites

Fig. 5: A healthy ear following treatment with Advocate®

Zoonotic significance

Although human infection has been reported, this is extremely rare.

Diagnosis

Diagnosis of Otodectes mite infestation is made by detection of mites within the cerumenous debris from an infected ear canal, or by visualization of mites on otoscopic examination.

Efficacy of Advocate®

Cats

In one study, 12 cats with natural ear mite infestations were randomly allocated to one of two groups of 6 cats each.3

One group was treated with a placebo and the other group with Advocate according to label instructions. On day 30 post-treatment, a mean number of 57.3 mites was found in the cats of the untreated control group.

In the Advocate treated group, a mean number of 0.8 mites was found and the efficacy was, therefore 98.6%.

In another study, 40 cats infected with Otodectes cynotis were divided into four groups of ten cats each.4

  • Group 1 was treated with a single dose of a placebo on day 0
  • Group 2 received Advocate on day 0
  • Group 3 was treated with placebo on days 0 and 28
  • Group 4 was treated with Advocate on days 0 and 28
Detailed procedures were followed to determine the number of live mites present for the cats of groups 1 and 2 on day 30, and groups 3 and 4 on day 60.

The mean geometric counts (immatures and matures) as well as efficacy values (%) are shown in Table 1. A single application of Advocate resulted in an efficacy of 99.5% against Otodectes cynotis in cats, 30 days after treatment. Two applications of the product produced an efficacy of 99.6%, as determined 32 days after the second treatment.

Table 1: Efficacy of Advocate® against Ear Mites in Cats

  Group 1 Negative Control (single dose of placebo)  Group 2 Single applications of Advocate®  Efficacy % 
Immature and adult mites  230.2  1.0  99.5 
  Group 3 Negative Control (responded dose of placebo)  Group 4 Two applications of Advocate®  Efficacy % 
Immature and adult mites  86.6  0.4  99.6 

Dogs

Thirty-two dogs with infestations of Otodectes cynotis were allocated to one of four groups of eight dogs each.

Dogs were treated with either a single dose of Advocate on day 0, or twice on days 0 and 28, with the other two groups acting as untreated controls. The dogs were assessed for the presence of live mites in their ears.5

The efficacy was found to be 98.3% for dogs receiving a single treatment and 98.0% for those receiving two treatments four weeks apart.

Questions about the product?

If you have any questions about the product, please contact our Veterinary Service.

References

  1. Urquhart, G.M., Armour, J., Duncan, J.L., Dunn, A.M., Jennings, F.W. "Veterinary Parasitology" – Second Edition. Blackwell Science, Oxford, London, Paris, Berlin (1996)
  2. Wall, R., Shearer, D. "Veterinary Ectoparasites – Biology, Pathology & Control" – Second Edition. Blackwell Science, Oxford, London, Paris, Berlin (2001).
  3. Bayer Study No. 23434
  4. Bayer Study No. 29815
  5. Bayer Study No. 29814

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Animations for Download

Gripping life cycle animations of this parasite you'll find in the download area.

Last changed: 19.11.2008